Peripartum cardiomyopathy: a review
نویسنده
چکیده
Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy of unclear etiology affecting women without preexisting heart disease during the last month of pregnancy or during the first 5 months postpartum. Its incidence shows marked geographic and ethnic variation, being most common in Africa and among women of African descent. Most women present in the first month postpartum with typical heart failure symptoms such as dyspnea, lower extremity edema, and fatigue. These symptoms are often initially erroneously diagnosed as part of the normal puerperal process. Diagnosis can be aided by the finding of a significantly elevated serum brain natriuretic peptide. The etiology of PPCM is unclear; however, recent research suggests abnormal prolactin metabolism is seminal in its development, and prolactin antagonism with bromocriptine shows promise as a novel treatment for PPCM.
منابع مشابه
گزارش یک مورد Peripartum Cardiomyopathy کاردیومیوپاتی برقآسا متعاقب زایمان و بهبودی کامل در پیگیری دو ساله
Peripartum Cardiomyopathy (PPCM) is a rare and specific form of dilated and fatal cardiomyopathy which leads to systolic complication of the left ventricle. The disease usually begins slowly but its progression is fatal. Thus, the prognosis of the disease is often poor. Because of the low prevalence of the disease, extensive epidemiologic and clinical studies are not available. Few papers, most...
متن کاملImmunosuppression therapy in the management of peripartum cardiomyopathy: A case series and literature review.
Peripartum cardiomyopathy is a heart failure syndrome occurring late in pregnancy or during the early post-natal period. The pathophysiology of peripartum cardiomyopathy is not fully understood and various mechanisms have been postulated including an underlying inflammatory process. We here report four cases presenting with acute left ventricular systolic dysfunction. Three out of four of the p...
متن کاملClinical characteristics of peripartum cardiomyopathy in the United States: diagnosis, prognosis, and management.
Peripartum cardiomyopathy is a pregnancy-associated myocardial disease characterized by the development of heart failure due to marked left ventricular systolic dysfunction. Although the disease is relatively uncommon, its incidence is increasing, and it can be associated with important and lasting morbidity and with mortality. Peripartum cardiomyopathy seems to affect women in different parts ...
متن کاملUnrecognized peripartum cardiomyopathy: Case series and comprehensive review of the literature
Peripartum cardiomyopathy (PPCM) is an uncommon type of heart failure of unknown cause occurring late in pregnancy or in the postpartum period. Because of its low incidence and the unspecific symptoms PPCM is often undetected or misdiagnosed. Unfortunately, PPCM is a disease whose underlying etiology and natural history remain incompletely understood. Nevertheless, it is incumbent on the intens...
متن کاملPeripartum cardiomyopathy: a review.
Peripartum cardiomyopathy is idiopathic heart failure occurring in the absence of any determinable heart disease during the last month of pregnancy or the first 5 months postpartum. The incidence varies worldwide but is high in developing nations; the cause of the disease might be a combination of environmental and genetic factors. Diagnostic echocardiographic criteria include left ventricular ...
متن کاملPeripartum cardiomyopathy: Euro Observational Research Program
Peripartum cardiomyopathy is a rare but potentially life-threatening form of heart failure affecting women late in pregnancy or in the first months after delivery. Peripartum cardiomyopathy is difficult to diagnose and its onset and progression are variable between individuals. The pathophysiology remains poorly understood, hence treatment options are limited and possibly harmful to the foetus....
متن کامل